Search for the molecules involved in leukemic transformation of myelodysplastic syndromes

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460691
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Kawasaki Medical School
• Principal Investigator: TOHYAMA KAORU 川崎医科大学, 医学部, 教授 (80227561)
• Co-Investigator(Renkei-kenkyūsha): TSUJIOKA Takayuki 川崎医科大学, 医学部, 講師 (50330551) ; SUEMORI Shin-ichiro 川崎医科大学, 医学部, 講師 (60330552)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 網羅的遺伝子解析 / 腫瘍関連遺伝子 / 造血障害 / 白血病移行

Outline of Final Research Achievements

Myelodysplastic syndromes (MDS) often transform to acute myeloid leukemia, but its mechanisms remain almost uncertain. We utilized an MDS-derived cell line and various sublines together with the bone marrow sample from the original MDS patient, and performed whole exome sequencing of each cell line. Consequently, we found several important gene mutations such as CEBPA, NRAS, Histone1H3C (K27M) and TET2.
Now we are investigating the role of each gene mutation towards searching for the molecules involved in leukemic transformation of MDS.

Free Research Field

病態検査学