Analysis of transcription factor that regulates intelectin-1 expression in mesothelioma

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460692
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Kanagawa Cancer Center Research Institute
• Principal Investigator: Tsuji Shoutaro 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 主任研究員 (30285192)
• Research Collaborator: WASHIMI KOTA 地方独立行政法人神奈川県立病院機構, 神奈川県立がんセンター(臨床研究所)・その他部局, 医師 (30716733) ; IMAI KOHZOH 地方独立行政法人神奈川県立病院機構, 神奈川県立がんセンター(臨床研究所)・その他部局, 顧問 (60117603) ; MATSUURA RIEKO 地方独立行政法人神奈川県立病院機構, 神奈川県立がんセンター(臨床研究所)・がん治療学部, 研究補助員
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 中皮腫

Outline of Final Research Achievements

In this study, we found a new highly specific and sensitive marker for mesothelioma, HEG1. The specificity (99%) and sensitivity (92%) of HEG1 to mesothelioma were higher than those of other mesothelioma markers, containing intelectin-1. We also found that gene silencing of HEG1 significantly suppressed proliferation of mesothelioma cells; this result suggested that HEG1 was associated with oncogenesis or proliferation of mesothelioma cells. Results of this study can contribute to the improvement of pathologic diagnosis and the development of medical treatment for mesothelioma.

Free Research Field

腫瘍検査学