2016 Fiscal Year Final Research Report
The elucidation of the mechanism of activation in left side and right side of anterior cingulate cortex and the modulation of descending inhibitory pain pathway in chronic pain
| Project/Area Number |
26460693
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Fukuoka University (2015-2016)
Hirosaki University (2014) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HONDA KENJI 福岡大学, 薬学部, 助教 (60140761)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 慢性疼痛 / 帯状回 / 左右側 |
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| Outline of Final Research Achievements |
In this study, we investigated functional changes in anterior cingulate cortex (ACC) of sciatic nerve ligation model mice using biochemical and electrophysiological technique. Spot patterns of the left and the right side of ACC in day 28 after nerve ligation were not same from the result of two-dimensional electrophoresis. These spots included CRMP-2 from the result of mass spectrometry analysis. However, the level of expression of CRMP-2 and pCRMP-2 were not changed between left side and right side of ACC in Western blot analysis. In addition, peak current of mIPSC in fear conditioning rats tended to decrease compared to control rats, whereas the current was not difference between left side and right side in layer II ~ III of pyramidal neuron in ACC. It is possible that excitatory transmission in ACC may be easy to occur by inhibitory system declined in chronic pain and stress condition.
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| Free Research Field |
神経薬理学
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