The identification of signal pathways inducing the visceral pain of hollow organs and its application to the treatment of visceral hyperesthesia

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460694
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pain science
• Research Institution: Osaka Prefecture University (2016); Kansai University of Nursing and Health (2014-2015)
• Principal Investigator: Miyai Kazumasa 大阪府立大学, 総合リハビリテーション学研究科, 教授 (60283933)
• Research Collaborator: KAWATANI Masahito ; YOSHIZUMI Masaru ; SHIMADA Shoichi
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 内臓知覚過敏 / アデノシン３リン酸 / 粘膜上皮 / 管腔臓器 / 一酸化窒素 / 環状ヌクレオチド / セロトニン

Outline of Final Research Achievements

The ATP release from mucosal epithelium of hollow organs in response to various stimuli contributes to the visceral sensation. In this study, we examined the effects of 1) PGE2-EP1 pathway, 2) NO-cGMP pathway, and 3) 5-HT receptor pathway on the epithelial ATP release in urinary bladder, esophagus, and colorectum. As a result, we found that NO-cGMP pathway inhibited the epithelial ATP release in all hollow organs analyzed in this study. Then we compared the epithelial ATP release in the model animals of bacterial cystitis or irritable bowel syndrome with that in healthy control animals. In these model animals with visceral hyperesthesia, the epithelial ATP release were increased in comparison to that in control animals.

Free Research Field

神経科学・生理学