Elucidation of pain control mechanism via sodium channel of novel target molecule contained in herbal medicine Goshajinkigan

2017 Fiscal Year Final Research Report

• Project/Area Number: 26460703
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pain science
• Research Institution: International University of Health and Welfare
• Principal Investigator: AMANO TAKU 国際医療福祉大学, 薬学部, 教授 (10294547)
• Co-Investigator(Renkei-kenkyūsha): NAKATANI YOSHIHIKO 国際医療福祉大学, 薬学部, 助教 (40582169) ; SAKAKIBARA IWAO 日本薬科大学, 薬学部, 教授 (50581972) ; YAHAGI TADAHIRO 日本大学, 薬学部, 助教 (40632766)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 牛車腎気丸 / 六味丸 / 疼痛 / 電気生理 / ナトリウムチャネル

Outline of Final Research Achievements

Goshajinkigan, one of the traditional Japanese Kampo formulas, has been used for neuropathic pain. However, how goshajinkigan suppresses the neuropathic pain are still unclear. In this study, we investigated the effect of Goshajinkigan and those ingredients to the voltage-gated sodium channels current (VGSCs) of Nav1.7 which predominantly expresses in peripheral nerve, particularly dorsal root ganglion using HEK293 cells expressing human Nav1.7 VGSCs. Our finding suggested that goshajinkigan may exhibit suppression of the neuropathic pain via Nav1.7 Na+ current inhibition by multiple components included in goshajinkigan.

Free Research Field

中枢神経薬理