2016 Fiscal Year Final Research Report
Alpha2 delta-1 mediated synaptic plasticity in the dorsal horn of peripheral nerve injury model rats
| Project/Area Number |
26460712
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 神経傷害性疼痛 / 脊髄後角 / シナプス / 可塑性 / 接着因子 |
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| Outline of Final Research Achievements |
The present study demonstrated the following new findings in the neuropathic pain model rats:1) nerve injury increased alpha2 delta-1 and decreased phosphorylated L1-CAM in injured DRG neuron. 2) Alpha2 delta-1 showed co-localization with phosho-L1-CAM in the dorsal horn. 3) Nerve injury increased the attachment of synaptophysin-ir with alpha2 delta-1and phospho-L1-CAM ir varicosity. 4) Administration of pregabalin decreased Alpha3 delta-1, L1-CAM and phosphp-L1-CAM in the dorsal horn after nerve injury. 5) Administration of pregabalin inhibited the formation of synaptohpysin-L1-CAM-ir contact in the dorsal horn of neuropathic pain model rats.
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| Free Research Field |
疼痛学
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