Synthesis and radioprotective activity of new vitamin E derivatives

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460734
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical Physics and Radiological Technology
• Research Institution: Tokyo University of Science
• Principal Investigator: Keiko Inami 東京理科大学, 薬学部薬学科, 准教授 (00271247)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ビタミンE / 6-クロマノール / ラジカル捕捉 / 放射線防御 / ベンゾクロマノール

Outline of Final Research Achievements

Radiotherapy is a method of cancer treatment based on destruction of malignant cells by ionizing radiation. Radiation therapy causes adverse effects that can be severe and cause permanent damages to the patient. Radioprotective agents are necessary for minimizing the severity and duration of toxicities associated with radiation therapy. The adverse toxicity was thought to be resulted from reactive oxygen species, which generated by the excitation of water molecules by radiation.
We focused on the radical scavenging function of vitamin E. Vitamin E derivatives were newly synthesized, and their radical scavenging activities were evaluated. Some of the vitamin E derivatives showed higher galvinoxyl and hydroxyl radical scavenging activities than vitamin E. In high-throughput screening for radioprotectors using rat thymocytes, some of the vitamin E derivatives showed the radio protecting activity. Therefore the vitamin E derivatives can be candidates as radioprotective agents.

Free Research Field

有機化学