Clarification of the cell death mechanism by radical effect

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460735
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical Physics and Radiological Technology
• Research Institution: Hiroshima International University
• Principal Investigator: haneda kiyofumi 広島国際大学, 保健医療学部, 准教授 (30280192)
• Co-Investigator(Renkei-kenkyūsha): YOSHIOKA Munenori 広島国際大学, 保健医療学部, 助教 (80435057)
• Research Collaborator: KATAHIRA Kei 兵庫県立粒子線医療センター, 放射線技術部, 診療放射線技師
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: radical effect / gel dosimeter / Monte Carlo code

Outline of Final Research Achievements

The purpose of this study was to estimate an impact on radical effect in the proton beams using a combined approach with physical data and gel data. This study used a polymer gel dosimeter. The spatial distribution of the physical dose was calculated by Monte Carlo code system PHITS.The simulation results were compared with measured the depth-dose distribution and good agreement was found, and the spatial distribution of a gel dose with threshold LET value of proton beam was calculated by the same code. Then, the relative distribution of the radical effect was calculated from the physical dose and gel dose. The relative distribution of the radical effect was calculated at each depth as the quotient of relative dose obtained using physical and gel dose. The agreement between the relative distributions of the gel dosimeter and Radical effect was good at the proton beams.

Free Research Field

radiation biology