2016 Fiscal Year Final Research Report
Association of alpha-klotho and angiopoietin-like protein 2 with mortality in the younger elderly
| Project/Area Number |
26460760
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 高齢者 / 長寿 / コーホート研究 / 生活習慣 |
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| Outline of Final Research Achievements |
Alpha-klotho (Klotho) has been identified as a biomarker of aging. Angiopoietin-like protein 2 (Angptl2) has also been identified as an indicator of chronic inflammation. However, evidence for an association between Klotho and Angptl2 with mortality has not been established. We conducted a stratified case-cohort study using data from the NISSIN Project, a prospective cohort study. A total of 2,851 participants aged 64/65 years at baseline formed the original cohort, from 1996 to 2005. A sub-cohort of 714 participants and 374 deaths (88 deaths within the sub-cohort) were analyzed. A weighted Cox proportional hazard model was used to evaluate the association of Klotho and Angptl2 with mortality. The median (25-75 percentile) concentration of Klotho and Angptl2 was 670 (540.0-883.5) pg/mL, 3.76 (3.07-4.57) ng/mL, respectively. There is a positive association between Angptl2 and mortality, whereas no association was found between Klotho and mortality.
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| Free Research Field |
公衆衛生学
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