2016 Fiscal Year Final Research Report
Evaluation of the relationship between Helicobacter pylori infection and osteopenia in Japanese healthy adults.
| Project/Area Number |
26460761
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | Helicobacter pylori / 骨減少症 / 胃粘膜萎縮 / 血清エストラジオール濃度 / カルシウム摂取量 / 生活習慣 |
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| Outline of Final Research Achievements |
In Japanese males, bivariate and multivariate analyses revealed that only age was significantly different between subjects with or without osteopenia. H. pylori infection is not a risk for osteopenia. In Japanese females, bivariate analysis showed H. pylori infection was associated with osteopenia. However, multivariate logistic regression analysis revealed that H. pylori infection was not significantly associated with osteopenia. Age, BMI, last educational level, serum level of estradiol and calcium intake were significantly associated with osteopenia. Furthermore, no significant association was found between gastric mucosal atrophy and osteopenia in multivariate logistic regression. Presence of significant confounding factors in the multivariate analysis might preclude the association between H. pylori infection and osteopenia.
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| Free Research Field |
医歯薬学
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