A prospective study on the association between declined autonomic nervous system function and onset of diabetes

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460767
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Ehime University
• Principal Investigator: Saito Isao 愛媛大学, 医学系研究科, 教授 (90253781)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 疫学 / 糖尿病 / 自律神経系機能 / 心拍変動 / メタボリックシンドローム

Outline of Final Research Achievements

We examined the association of heart rate variability (HRV), which expresses an autonomic nervous system function, with insulin resistance and incident diabetes in a general population. Declined HRV was related to the accumulation of each risk factor of waist circumstance, blood pressure, HDL cholesterol, triglycerides, and fasting glucose; and an increase in percentage of the metabolic syndrome. During the follow-up of five years, we identified 58 new diabetes onsets among 1001 participants, but sex and age-adjusted odds ratios of low HRV for diabetes onset were not significant. Decreased parasympathetic nervous system function, which elevated the sympathetic nervous activity, was associated with increased insulin resistance, low insulin sensitivity, and presence of the metabolic syndrome.

Free Research Field

公衆衛生学