A basic study on biomarkers for early diagnosis and comprehensive managements of COPD

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460770
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Kumamoto University
• Principal Investigator: Omori Hisamitsu 熊本大学, 大学院生命科学研究部(保), 教授 (70271442)
• Research Collaborator: TSUDA Tohru 霧ケ丘つだ病院, 院長 ; HAYASHI Toshinari 所沢呼吸器内科クリニック, 院長 ; OGATA Yasuhiro 日本赤十字社熊本健康管理センター, 所長 ; MIHARA Shuichi みはらライフケアクリニック, 院長 ; ONOUE Ayumi 熊本大学, 大学院・生命科学研究部・生体情報解析学分野
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 慢性閉塞性肺疾患 / COPD / 呼吸機能 / 気流閉塞 / 併存症 / バイオマーカー / 疫学 / 健康診断

Outline of Final Research Achievements

The purpose of this study was to examine the relationship of lung function、and severity of COPD with plasma fibrinogen levels, urine albumin levels, and vitamin D (25(OH)D) status. In this study, plasma fibrinogen levels were not associated with lung function. We observed increased levels of urine albumin among subjects with airflow limitation compared to subjects with normal lung function. There was no association between CT emphysema and serum 25(OH)D levels. We observed a relationship between lower serum 25(OH)D levels and lower lung function among subjects with airflow limitation.

Free Research Field

医歯薬学　社会医学　疫学・予防医学　健康管理