New method for aiding detection of abnormal thyroid function in patients making use of set of routine tests – applying it in screening during general health check-ups or visiting hospitals

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460777
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Tohoku Medical and Pharmaceutical University
• Principal Investigator: SATO Kenichi 東北医科薬科大学, 薬学部, 教授 (30158935)
• Research Collaborator: YOSHIDA Katsumi 東北公済病院, 医学管理センター, 医師 ; MORI Kouki JR仙台病院, 健康管理センター長 ; NAKAGAWA Yoshinori 仙台甲状腺クリニック, 院長 ; YAMAGISHI Toshio 東北公済病院, 内科部長
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 甲状腺機能異常 / 基本的検査 / スクリーニング / 時系列データ / パターン認識手法

Outline of Final Research Achievements

We developed a new simple, low-cost method for detecting patients with overt thyroid dysfunction (PTD) using the combination of six routine tests already measured without measuring thyroid hormone. The existing procedure comprised 6 routine tests (alkaline phosphatase (ALP), serum creatinine (S-Cr), total cholesterol (TC), heart rate (HR), lactate dehydrogenase (LDH) and red blood cell (RBC)). We performed this screening for many participants more than 20000 attending health-checkup at Ningen Docks in JR Sendai Hospital and Tohoku Kousai Hospital, and found more than 40 PTDs, most of them was suspected of thyroid dysfunction by a medical examination. Furthermore, it was found that a very highly-detailed prediction not to be affected by the individual difference was possible when there was the value last time.

Free Research Field

情報科学