Development of molecular-targeting cancer prevention by means of food factors

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460792
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: YOSHIDA TATSUSHI 京都府立医科大学, 医学(系)研究科(研究院), 講師 (80315936)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 食品成分 / 癌 / 分子標的予防 / TRAIL / RUNX1 / 転写制御 / IRF1

Outline of Final Research Achievements

TRAIL is a promising anti-cancer agent but has still been going on clinical studies. To improve the TRAIL efficacy, I carried out the screening of food factors which could induce endogenous TRAIL expression and the analysis of the induction mechanism. Then, I found a marine carotenoid, a flavonoid, an isothiocyanate and a metabolite of fatty acid as TRAIL inducers. In addition, I found two low-molecular weight compounds except for food factors also up-regulated TRAIL expression. I elucidated the mechanism by which the fatty acid metabolite induced TRAIL expression. A transcription factor RUNX1 interacted with IRF1 and collaborated with it to up-regulation of TRAIL expression at the transcription level.

Free Research Field

分子生化学