Effects of cruciferous vegetable elements in sensitizer-induced ear edema

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460795
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Kanazawa University
• Principal Investigator: Tanii Hideji 金沢大学, 医学系, 准教授 (90110618)
• Co-Investigator(Renkei-kenkyūsha): SUGITANI Kayo 金沢大学, 保健学系, 助教 (20162258)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: アリルニトリル / 感作性物質 / 炎症

Outline of Final Research Achievements

There are numerous sensitizers in the environment. It is possible that individuals in the environment are at a risk of exposur to sensitizers. To prevent allergic reactions due to sensitizers, we focused on allyl nitrile derived from cruciferous vegetables. This chemical has the ability to induce antioxidant/phase II detoxification enzymes. Repeated low dose exposure to allyl nitrie decreased sensitizer-induced ear edema, suggesting its capability of reducing allergic reactions. But allyl isothiocyanate showed no anti-allergic reactions. Additionally, isothiocyanates other than allyl isothiocyanate from cruciferous vegetables reportedly decrease dermal allergic reactions.

Free Research Field

産業衛生学