2016 Fiscal Year Final Research Report
Detection of antiviral-resistant influenza viruses
| Project/Area Number |
26460816
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene and public health
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
Takashita Emi 国立感染症研究所, インフルエンザウイルス研究センター, 主任研究官 (30361249)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 抗インフルエンザ薬 / 薬剤性ウイルス |
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| Outline of Final Research Achievements |
The surveillance of antiviral-resistant viruses is important for public health authorities and clinicians to control influenza. Here, we improved fluorescence-based and chemiluminescence-based neuraminidase (NA) inhibition assays for determining influenza susceptibility to NA inhibitors, oseltamivir, zanamivir, peramivir and laninamivir. Then we established a cell-based screening system to evaluate the susceptibility of influenza viruses to a novel antiviral drug, favipiravir, a viral RNA-dependent RNA polymerase inhibitor.
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| Free Research Field |
ウイルス学
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