Benchmark dose of alcohol tolerance for hyperuricemia in a large cohort followed up for 17 years

2024 Fiscal Year Final Research Report

• Project/Area Number: 26460825
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Chiba University
• Principal Investigator: Takami Miyuki 千葉大学, 大学院医学研究院, 技術職員 (70571355)
• Co-Investigator(Kenkyū-buntansha): 能川 和浩 千葉大学, 大学院医学研究院, 准教授 (00612194) ; 諏訪園 靖 千葉大学, 大学院医学研究院, 教授 (90302546)
• Project Period (FY): 2014-04-01 – 2025-03-31
• Keywords: 飲酒量 / 高尿酸血症 / ベンチマーク用量 / 日本人男性

Outline of Final Research Achievements

The mean follow-up period for subjects was 3.86 years, and the incidence rate per 1,000 was 61.1. Pooled logistic regression analysis, adjusting for other factors, showed a positive dose-response relationship between alcohol intake (g/day) and hyperuricemia. The odds ratio for the development of hyperuricemia for each increase in alcohol intake of 1 g/day was 1.29 (95% confidence interval: 1.22-1.36). When the BMR was 5%, the calculated BMDL/BMD for alcohol intake was 2.5/2.9 g/day (55.3 g/62.8 g/day), and when the BMR was 10%, it was 4.1/4.6 g/day (90.0/102.1 g/day).

Free Research Field

衛生学

Academic Significance and Societal Importance of the Research Achievements

飲酒量と高尿酸血症発症についての明らかな正の量反応関係を認め、1日あたり2.5合の飲酒で高尿酸血症発症のリスクが明確に上昇することがわかった。大規模コホートを長期追跡し、最新の統計学的手法を応用することで、日本人男性労働者において、飲酒による高尿酸血症発症の予防に関して、有意義な情報が得られたと考える.