An epidemiological study on the relation of iron in the body with subsequent changes in biomarkers

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460850
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Hokkaido University
• Principal Investigator: NAKAMURA Koshi 北海道大学, 医学研究科, 准教授 (80422898)
• Co-Investigator(Renkei-kenkyūsha): NAKAGAWA Hideaki 金沢医科大学, 医学部, 教授 (00097437) ; SAKURAI Masaru 金沢医科大学, 医学部, 准教授 (90397216) ; MORIKAWA Yuko 金沢医科大学, 看護学部, 教授 (20210156) ; NAGASAWA Shin-ya 金沢医科大学, 医学部, 講師 (30510341)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: フェリチン / 血糖 / インスリン / 縦断研究

Outline of Final Research Achievements

We investigated the relation of serum ferritin with subsequent changes in biomarkers associated with glucose metabolism among 575 normoglycemic men without iron overload disorders. The subsequent changes in fasting blood glucose, insulin and HOMA-IR after 3 years were grater in subjects having lower levels of serum ferritin after adjustment for body mass index and other potential confounding factors. However, HOMA-β was similar across serum ferritin levels. Elevated serum ferritin levels may worsen glucose metabolism through insulin resistance among normoglycemic Japanese men without iron overload disorders.

Free Research Field

医歯薬学