Development of a Reasoning System for Pharmacodynamic Mechanism of Adverse Drug Reaction Based on Ontology

2017 Fiscal Year Final Research Report

• Project/Area Number: 26460857
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical and hospital managemen
• Research Institution: The University of Tokyo
• Principal Investigator: Imai Takeshi 東京大学, 大学院医学系研究科(医学部), 准教授 (90401075)
• Research Collaborator: Hayakawa Masayo 国立がん研究センター, がん情報提供部 ; Ohe Kazuhiko 東京大学, 大学院医学系研究科, 教授
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: オントロジー / 知識推論 / 薬物有害事象 / 薬力学

Outline of Final Research Achievements

This study aimed to develop a reasoning system for pharmacodynamic mechanism of adverse drug reaction. We first developed pharmacodynamics ontology which represents causal chains between drug, target, and physiological states. Then we constructed a reasoning system for pharmacodynamic mechanism of adverse drug reaction related to dysuria by traversing the ontology. We also evaluated the system by comparing the inferred results with the known adverse events derived from the drug package inserts and the actual adverse event cases.

Free Research Field

医療情報学