2016 Fiscal Year Final Research Report
Analysis of vascular tissue fragility of cerebral arteries affected by cerebrospinal fluid.
| Project/Area Number |
26460874
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 脳動脈瘤 / プロテアーゼ / 脳脊髄液 / カルシウム / α-Klotho蛋白 |
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| Outline of Final Research Achievements |
The frequency and distribution of unruptured cerebral aneurysms of minimal size in forensic autopsy cases were analyzed, measuring the activities of galatinases in cerebrospinal fluid(CSF). The results showed that gelatinolytic activities of CSF generated from gelatinase A and B can serve as good markers of early-stage cerebral aneurysm（p<0.001）. Moreover the gelatinolytic activities of CSF demonstrated parallels with the concentration of α-Klotho protein by which Ca deposition is controlled locally in the body. Therefore, combined with the microscopic findings, these Ca-dependent biochemical values of CSF can help to predict the development of cerebral aneurysms.
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| Free Research Field |
法医学
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