Relation of the morphologic classification and genetic polymorphism of the arterial calcification

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460887
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Legal medicine
• Research Institution: Kitasato University (2016); Tokai University (2014-2015)
• Principal Investigator: Satoh Fumiko 北里大学, 医学部, 教授 (70328128)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 動脈石灰化 / 粥状硬化症 / 急性大動脈解離 / 大動脈瘤

Outline of Final Research Achievements

We tried to establish a histologic method of arterial calcification. We produced a specimen for a strong part of aortic calcification obtained through forensic autopsy and classified areas roughly as 1) diffuse calcification, 2) tininess calcification, 3) diffuse calcification of endosporium, or 4) ossification or myelogenesis. We examined the histology of the intimal tear site of the acute aortic dissection case and the aorta histology of the control case. For both, we semiquantified on cystic medial necrosis, elastin fragmentation, fibrosis, and medionecrosis. Results show that advanced atherosclerosis and weakness of media by calcification have an undeniable relation to the onset of aortic dissection and aortic aneurysms.

Free Research Field

法医病理学