Searching of genetic polymorphisms affecting the serum haptoglobin concentration.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460894
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Legal medicine
• Research Institution: Kurume University
• Principal Investigator: Koda Yoshiro 久留米大学, 医学部, 教授 (90231307)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ハプトグロビン / 血中濃度 / 遺伝子多型 / 関連解析 / アリルの生成年代

Outline of Final Research Achievements

Haptoglobin (HP) is produced by the liver and it bind to free hemoglobin to prevent the loss of hemoglobin and neutralize the adverse physiologic effects of it. It is known that the serum HP concentration is influenced not only by various diseases or physical conditions but individual variability. In this study, we performed association study on various populations to explain the individual variability. Accordingly, 2 SNPs, rs5472 and rs2000999, and HP deletion allele, HPdel, independently influenced the serum HP concentration. In addition, we estimated the generation time of the HPdel by sequence analysis of the region flanking the junctions to be relatively recent because no substations in the analyzed sequence.

Free Research Field

法医学、人類遺伝学