Central biomarker of functional pain disorders

2017 Fiscal Year Final Research Report

• Project/Area Number: 26460898
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Tohoku University
• Principal Investigator: Kano Michiko 東北大学, 学際科学フロンティア研究所, 助教 (20344658)
• Co-Investigator(Renkei-kenkyūsha): FUKUDO Shin 東北大学, 医学系研究科, 教授 (80199249) ; KANAZAWA Motoyori 東北大学, 医学系研究科, 准教授 (70323003)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 内臓痛 / 予期不安 / 過敏性腸症候群 / 脳画像 / 島皮質

Outline of Final Research Achievements

One of the main pathophysiology of functional pain disorders is suggested as the disorders of central pain processing. In this study, we investigated that the brain processing of visceral stimulation in participants with irritable bowel syndrome (IBS) who are suffering from chronic abdominal pain and change of bowel habit. Visual cues informed the possibility of upcoming visceral stimulation. Participates with IBS demonstrated that increased brain activity in the anterior midcingulate cortex and posterior cingulate cortex during visceral stimulation after uncertain cue than that after certain cue. In addition, IBS participants failed to reduce the activation in the insula cortex during safe condition. This results indicate that the context of anticipation influence the brain processing of visceral pain and which may contribute to pain symptoms in patients with IBS.

Free Research Field

心身医学