2016 Fiscal Year Final Research Report
Investigation of ion channel modulators in Japanese Kampo.
| Project/Area Number |
26460912
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Saga University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 漢方薬 / 生薬 / 消化管運動 / 電気的自発活動 |
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| Outline of Final Research Achievements |
Rikkunshito and Bukuryouin dose-dependently inhibited spontaneous contractions in circular muscles of the mouse gastric antrum. In the common constitutive herbs among the above two Japanese Kampo, Atractylodis lanceae rhizoma, aurantiinobilis pericarpium and ginseng radix inhibited those contractions. Rikkunshito depolarized the membrane and abolished sow waves recorded from circular muscles of the mouse gastric antrum. In contrast, Bukuryouin hyperpolarized the membrane and decreased the frequency and amplitude of slow waves. Atractylodis lanceae rhizoma slightly depolarized the membrane, but had no effect on the frequency of slow waves. Aurantiinobilis pericarpium and ginseng radix hyperpolarized the membrane. Aurantiinobilis pericarpium also decreased the frequency of slow waves. These results suggest that Rikkunshito and Bukuryouin inhibited spontaneous contractions in circular muscles of the mouse gastric antrum with different mechanisms.
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| Free Research Field |
消化管運動
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