Examination of function and mechanism of renin / angiotensin system in sarcopenia

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460913
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Kagoshima University
• Principal Investigator: Akasaki Yuichi 鹿児島大学, 医歯学域附属病院, 助教 (00631920)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 老化 / サルコペニア / 骨格筋 / レニン / アンジオテンシン

Outline of Final Research Achievements

We examined skeletal muscle changes of C57BL/6 control mice and angiotensin II receptor 1 knockout mice (AT1aR KO) in young (12 weeks old) and middle aged (12 months old) and old age (24 months old). In control mice, muscle strength was lower in middle aged and older than in younger. On the other hand, in AT1aR KO mice, muscle strength was maintained in middle and old age. Regarding gastrocnemius muscle weight, no significant difference was observed in control and AT1aR KO mouse. It was suggested that although muscle mass difference was not observed, it is possible to prevent muscle weakness by inhibiting the renin / angiotensin system over a long period of time.

Free Research Field

医歯薬学