Development and clinical application of noninvasive detection method for autonomic nerve acitivity

2017 Fiscal Year Final Research Report

• Project/Area Number: 26460915
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Wakayama Medical University
• Principal Investigator: Hano Takuzo 和歌山県立医科大学, 医学部, 学長特命教員(特別顧問) (90156381)
• Co-Investigator(Kenkyū-buntansha): 水越 正人 関西医療大学, 保健看護学部, 教授 (90254531) ; 川邊 哲也 和歌山県立医科大学, 医学部, 助教 (60508034)
• Research Collaborator: IWANE Naomi ; SHINYA Hiromi ; KOIKE Yumi
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 自律神経 / 瞳孔機能検査 / 高血圧 / カルシウム拮抗薬 / 加齢 / 血圧変動

Outline of Final Research Achievements

The influence of amlodipine(AM), cilnidipine(CL), azelnidipine(AZ)　on sympathetic nervous activation during exercise was evaluated by pupil function test for hypertensive patients. In comparison between CL and AM group, the pupil contraction velocity (VC) significantly increased after isometric exercise load in both groups, but the degree of change was greater in the amlodipine group than in the CL group. Pupil dilation rate (VD) did not change in CL group, but it increased significantly in AM group. In the comparison between azelnidipine and amlodipine group, VC was significantly elevated in AM group after load, but not changed in AZ group. VD showed elevated in the AM group but did not change in the AZ group. In the healthy subjects with isometric exercise load, the parasympathetic nerve was increased with age. The day-day variation of blood pressure was lower as the autonomic nerve regulating function was maintained.

Free Research Field

高血圧