Angiotensin II Modulates Hypertrophic Differentiation and Apoptosis of Chondrocytes: Relationship of hypertension to Osteoarthrosis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460928
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Morinomiya University of Medical Sciences
• Principal Investigator: Aoki Motokuni 森ノ宮医療大学, 保健医療学部, 教授 (00346214)
• Co-Investigator(Renkei-kenkyūsha): Ogihara Toshio 大阪大学, 医学系研究科, 名誉教授 (60107042)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: レニンーアンジオテンシン系 / アンジオテンシンII / アンジオテンシン受容体拮抗剤 / 高血圧 / 変形性関節症

Outline of Final Research Achievements

Little is known about the function of Angiotensin II (AII) in chondrocytes. In this study, we investigated the role of AII in chondrocytes using a rib fracture model mouse. Continuous infusion of Ang II to a mouse resulted in promotion of differentiation of chondrocytes. Moreover, AII infusion suppressed apoptosis of chondrocytes. Administration of an AII receptor blocker attenuated the suppression of apoptosis of chondrocytes. These data suggested that AII promoted differentiation of chondrocytes and reduced apoptosis of chondrocytes, independently of blood pressure, suggesting a new concept for comprehensive treatment osteoarthrosis (OA). Also, we evaluated the methodology of an OA model mouse. We made two animal models and histological studies indicated that both models reflected the pathological change of OA. These models is useful to investigate a new treatment for patients with hypertension and OA.

Free Research Field

高血圧