Mechanism of vascular endothelial autophagy in metabolic sydrome

2017 Fiscal Year Final Research Report

• Project/Area Number: 26460931
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Hayashi Shinichiro 国立研究開発法人国立循環器病研究センター, 病院, 医師 (20396740)
• Co-Investigator(Kenkyū-buntansha): 里 直行 大阪大学, 医学系研究科, 寄附講座准教授 (70372612)
• Co-Investigator(Renkei-kenkyūsha): YAMAMOTO Akitsugu 長浜バイオ大学, バイオサイエンス研究科, 教授 (30174775)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: オートファジー / 血管内皮細胞 / 生活習慣病

Outline of Final Research Achievements

The mechanism of endothelial dysfunction in metabolic syndrome, a forerunner of cardiovascular disease and atherosclerosis, still remains uncertain. In this study, we found several endothelial specific molecules whose regulation in the setting of metabolic syndrome could modulate endothelial autophagy. These findings indicate the possibilities that targeting endothelial autophagy would be a novel therapeutic option to prevent up-coming cardiovascular disease and atherosclerosis in patients with metabolic syndrome.

Free Research Field

血管分子生物学