Roles and regulation of adipose tissue in the survival, growth, invasion and lipid droplet deposition of gastric cancer cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460941
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Saga University
• Principal Investigator: Shuji Toda 佐賀大学, 医学部, 教授 (80188755)
• Co-Investigator(Renkei-kenkyūsha): SAKATA Yasuhis 佐賀大学, 医学部, 助教 (50404158)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 胃癌 / 脂肪組織 / 脂肪滴 / アポトーシス / 増殖 / 浸潤 / アディポカイン / 培養モデル

Outline of Final Research Achievements

Adipose tissue is suggested to be associated with the pathogenesis of gastric cancer. The cancer cells generated in the mucosa infiltrate into submucosa, muscular layer and subsrosa, and they results in cancer peritonitis. On the other hand, adipose tissue abundantly exists in the submucosa, subserosa and intraabdominal space. In general, lipid derived from adipose tissue is suggested to actively influence cancer cell behavior. Thus, adipose tissue is expected to actively affect the behavior. However, adipose tissue-cancer interaction remains to be elucidated. Here, we studied the interaction and mechanisms.

Free Research Field

実験病理学