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2016 Fiscal Year Final Research Report

Prediction of drug sensitivity to gastric cancer using BH3 profiling

Research Project

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Project/Area Number 26460943
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionSapporo Medical University

Principal Investigator

KAWANO YUTAKA  札幌医科大学, 医学部, 助教 (80398320)

Research Collaborator Letai Anthony  ダナ・ファーバー癌研究所
Project Period (FY) 2014-04-01 – 2017-03-31
Keywords抗癌剤感受性 / 胃癌 / BH3プロファイリング
Outline of Final Research Achievements

Drug sensitivity and BH3 profiling for seven gastric cancer cell lines were examined. BIM BH3 profiling results correlated with docetaxel sensitivity and also BAK protein expression. Patients with higher BAK protein expression in gastric cancer showed improved progression-free survival and overall survival.
BAK expression in gastric cancer is thus predictive of chemotherapeutic response to docetaxel and clinical prognosis in patients with docetaxel including chemotherapy.

Free Research Field

医歯薬学

URL: 

Published: 2018-03-22  

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