2016 Fiscal Year Final Research Report
Analysis of Lgr5-positive cells in the intestinal metaplasia
| Project/Area Number |
26460948
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | Lgr5 |
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| Outline of Final Research Achievements |
Intestinal metaplasia is precancerous lesion of the stomach. We investigated the expression of Lgr5 in intestinal metaplasia and gastric carcinoma. By crossbreeding Cdx2-transgenic mouse and Lgr5-EGFP-ires-CreERT2 mouse, Lgr5-expression in intestinal metaplasia and gastric carcinoma was identified. By crossbreeding Lgr5-EGFP-ires-CreERT2-mouse, ROSA26-Loxp-stop-Loxp-LacZ-mouse, Cdx2-transgenic mouse, it was suggested that Lgr5 is induced by Cdx2.
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| Free Research Field |
消化管
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