2016 Fiscal Year Final Research Report
Biomarker research for gastric cancer with proteomics and pathway analysis
| Project/Area Number |
26460949
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Keio University |
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Principal Investigator |
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 胃癌 / バイオマーカー / sulfasaradine / HER2 |
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| Outline of Final Research Achievements |
We tried to elucidate unknown biological characteristics in gastric cancer, and explore novel biomarker to predict drug sensitivity through the comprehensive genetic and biological analyses.
We found correlation between expression level of CD44v8-10 and sensitivity of sulfasarazine in cell lines of gastric cancer. We currently analyze biomarkers to predict efficacy of trastuzumab, anti-HER2 antibody, in patients with HER2 positive gastric cancer.
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| Free Research Field |
消化器腫瘍
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