Effect prediction and monitoring of serum biomarker TYMP in gastric cancer XP therapy

2018 Fiscal Year Final Research Report

• Project/Area Number: 26460951
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Toho University
• Principal Investigator: KIKUCHI Yoshinori 東邦大学, 医学部, 講師 (20408769)
• Co-Investigator(Kenkyū-buntansha): 島田 英昭 東邦大学, 医学部, 教授 (20292691) ; 五十嵐 良典 東邦大学, 医学部, 教授 (50212741) ; 名波 竜規 東邦大学, 医学部, 助教 (90385831)
• Project Period (FY): 2014-04-01 – 2019-03-31
• Keywords: 胃癌 / thymidine phosphorylase / Capecitabine / 血小板数 / ＥＬＩＳＡ / 免疫組織学的染色

Outline of Final Research Achievements

A series of 77 patients with gastric adenocarcinoma were enrolled in the study. Pretreatment serum　TP was determined by enzyme-linked immunosorbent assay and the patient characteristics, including　platelet count, gender, age, tumor stage and histological grade, and immunoreactivity of surgically resected　tissue specimens, were recorded.　The serum TP level was significantly higher in poorly differentiated and signet ring cell adenocarcinomas than in more differentiated types. TP expression was observed within well- and moderately differentiated adenocarcinoma cancer cells, but was significantly weaker in poorly differentiated adenocarcinomas and signet ring cell carcinomas. Although the differences were not statistically significant, high TP expression and high platelet counts were poor prognostic factors. TP expression was not correlated with serum TP levels, but was slightly correlated with the platelet count.

Free Research Field

消化器

Academic Significance and Societal Importance of the Research Achievements

胃癌組織でのＴＰ発現は血清ＴＰ値よりも血小板数と関連性があることが示された。したがって、胃癌患者における血小板数とカペシタビン治療効果との関係を評価するためには今後、より多くの患者を評価する必要がある。