High risk markers for cancer in Barrett's esophagus

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460954
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kawasaki Medical School
• Principal Investigator: Shiotani Akiko 川崎医科大学, 医学部, 教授 (80275354)
• Research Collaborator: Nisho Kazuto 近畿大学, 医学部ゲノム生物学教室, 教授 ; Fujita Yoshihiko 近畿大学, 医学部ゲノム生物学教講, 講師 ; Murao Takahisa 川崎医科大学, 消化管内科, 講師 ; Wallace Michael B Mayo Clinic, 消化器・肝臓病学部門, 部長 ; Wolfsen Herbert Mayo Clinic, 消化器・肝臓病学部, 医師 ; Berzosa Manuel Mayo Clinic, 消化器・肝臓病学部, 医師
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: バレット食道腺癌 / SERPINB7 / SCNN1B

Outline of Final Research Achievements

In the pilot study, microarray analysis indicated the possibility of SERPINB7 over expression as a biomarker for the risk of EAC in the previous case control study investigating brushing samples taken from targeted BE mucosa of USA patients by endoscopy. The validation study group consisted of 12 EAC patients (LSBE 2,) and 65 sex and age-matched patients with BE patients(LSBE 11, SSBE 54). The expression levels of TRHDE, PDZK1,SERPINB7　were higher and SCNN1B　was significantly lower in the LSBE control group than those in the SSBE group. The expression levels of SCNN1B was lower, and SERPINB7 was higher in the BE of the EAC groups than those in the SSBE of the controls among the 3 groups. Overexpression of SERPINB7 and down-expression of SCNN1B in the LSBE patient were recognized in Japanese patients as well as USA patients. SCNN1B may be useful markers to select patients for surveillance for LSBE and EAC.

Free Research Field

医歯薬学