The plasticity mechanism and gene expression of interstitial cells of Cajal (ICC) with inflammatory stimulations in colitis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460964
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: University of Fukui
• Principal Investigator: HORIGUCHI SATOMI 福井大学, 学術研究院医学系部門, 特別研究員 (00595283)
• Co-Investigator(Renkei-kenkyūsha): IINO SATOSHI 福井大学, 学術研究院医学系部門, 教授 (40242854)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 炎症性腸疾患 / 消化管運動 / カハール介在細胞 / 発現解析 / マウス

Outline of Final Research Achievements

In this study, we examined the gene expression of interstitial cells of Cajal, which are thought to be the regulatory cells of gut motility, in trinitrobenzene sulfonic acid-induced experimental colitis of mice. We suggested that the proliferation of ICC and smooth muscle cells is involved in the recovery of organs on muscularis inflammation. By microarray, we found some candidate genes related to ICC recovery including cell growth factors and transcription factors. These results may lead to the development of new therapeutic strategy for motility disorder of gut.

Free Research Field

消化器内科学