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2016 Fiscal Year Final Research Report

Acid sphingomyelinase-derived liver macrophage inhibits growth of metastatic colon cancer in the liver.

Research Project

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Project/Area Number 26460965
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionTokyo Metropolitan Komagome Hospital (Clinical research laboratory)

Principal Investigator

Yosuke Osawa  東京都立駒込病院(臨床研究室), 肝臓内科, 医長 (60447787)

Project Period (FY) 2014-04-01 – 2017-03-31
Keywords転移性肝腫瘍 / 肝線維化 / スフィンゴ脂質 / βカテニンシグナル
Outline of Final Research Achievements

Sphingolipids regulate carcinogenesis and proliferation, survival, and apoptosis of cancer cells.In this study, the involvement of ASM in liver metastasis of colon cancer was examined. ASM in the liver inhibits tumor growth through cytotoxic macrophage. Thus, targeting ASM may represent a new therapeutic strategy for treating liver metastasis of colon cancer.

Free Research Field

肝臓病学

URL: 

Published: 2018-03-22  

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