Elucidation of the pathogenesis of inflammatory bowel disease based on selective IL-17F regulation via Dectin-1.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460966
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Ban Hiromitsu 滋賀医科大学, 医学部, 特任助教 (30598363)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 炎症性腸疾患 / サイトカイン / アンチセンスオリゴ

Outline of Final Research Achievements

IL-17β is highly expressed from Dectin-1 positive cells with IL-1β. In addition, we have studied the introduction of antisense DNA nucleotide sequences into cells using β-1,3-D-gulcan, Schizophyllan as a carrier, in a Dectin-1 dependent manner. Based on these two studies, IL-17F highly expressed from Dectin-1 positive cells in intestinal inflammation model mice was suppressed by intracellular introduction of antisense DNA by using SPG-mediated Drug delivery system We will elucidate the role of IL-17F expressed from Dectin-1 positive cells and aim to develop new therapeutic agents for inflammatory bowel disease.

Free Research Field

消化器内科