molecular biological analysis of Sessile serrated adenoma/polyp in the proximal colon

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460974
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kumamoto University
• Principal Investigator: Shono Takashi 熊本大学, 医学部附属病院, 助教 (40632667)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 大腸癌 / 発癌 / 大腸ポリープ / 内視鏡 / 消化器

Outline of Final Research Achievements

We resected 3 SSAPs with cancer in the proximal colon with use of endoscopic submucosal dissection (ESD). These specimens were divided into normal mucosa, SSAP and cancer, using with Laser Micro-Dissection method (LMD). DNA and RNA were extracted from each section, respectively. Especially, microRNA (miRNA) quantification was performed.
We molecularly analyzed extracted miRNAs and detected variable miRNAs in a characteristic manner during the process of carcinogenesis.

Free Research Field

大腸癌