The role of a transcriptional coactivator (PDIP1) that functions as a transcriptional coregulator of several nuclear receptors in the physiopathological process of the liver

2018 Fiscal Year Final Research Report

• Project/Area Number: 26460983
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Gunma University
• Principal Investigator: SATO KEN 群馬大学, 医学部附属病院, 助教 (40396619)
• Co-Investigator(Kenkyū-buntansha): 山崎 勇一 群馬大学, 医学部附属病院, 助教 (00582404) ; 堀口 昇男 群馬大学, 医学部附属病院, 助教 (10550022)
• Research Collaborator: Satoh Tetsurou ; Yoshino Satoshi ; Gyao Bin ; Tahara Hiroki ; Nakajima Yoshimi ; Ohyama Tatsuya ; Takizawa Daichi ; Tojima Hiroki
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: トランスレーショナルリサーチ / バイオテクノロジー / 癌 / マイクロアレイ

Outline of Final Research Achievements

PDIP1 regulates target gene expression through nuclear receptor that is a kind of intracellular proteins. In addition, there is a difference of the extent of liver fibrosis that is caused by the stimuli which accelerate liver fibrosis between PDIP1 knock out mice in which the function of PDIP1 is lost and wild type mice in which the function of PDIP1 is maintained. There is also a difference of the extent of liver tumor that is caused by the stimuli which induce liver tumor between PDIP1 knock out mice and wild type mice. The mechanisms of the differences of liver fibrosis and tumor were analyzed and clarified.

Free Research Field

肝臓病学

Academic Significance and Societal Importance of the Research Achievements

マウスを用いた実験であり、必ずしもヒトにおける病態を反映するとは限らないが、今回の科研費の研究により、最近生体内エネルギー代謝調節系における機能が注目されている核内受容体転写共役活性化因子の一つであるPDIP1と肝臓の線維化や発癌のメカニズムとの関係について示すことができた。今後今回の研究を元に、多臓器の線維化や発癌モデルへの応用や、PDIP1を創薬ターゲットとした開発の端緒となる成果を示すことができたといえる。