2016 Fiscal Year Final Research Report
MICA expression regulation by small nucleic acids to prevent HCC occurrence
| Project/Area Number |
26460984
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
Sato Masaya 東京大学, 医学部附属病院, 特任臨床医 (30722665)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | MICA / 免疫療法 / 肝癌 |
|---|
| Outline of Final Research Achievements |
The investigators identified MICA gene as a susceptible gene to hepatocellular carcinoma by GWAS analyses using 1,394 HCV-related patients and 5,486 non-infected patients. In this study, MICA expression could be regulated by microRNA25-106b. Further, using CRISPR-Cas9 and Cas9-VP16 fusion construct, trascription of MICA mRNA could be augmented about te times. These results may lead to the regulation of MICA gene expression, which in turn result in the prevention of hepatocellular carcinoma occurrence.
|
| Free Research Field |
肝疾患の研究
|
