2016 Fiscal Year Final Research Report
Role of PARK7 in nonalcoholic steatohepatitis and its application for diagnosis
| Project/Area Number |
26460989
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | PARK7 / NASH / NAFLD |
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| Outline of Final Research Achievements |
We analyzed the role of PARK7 in nonalcoholic steatohepatitis (NASH). PARK7 immunoreactivity was present mainly in the hepatocyte nucleus in patients with NAFLD. There was a stepwise increase in the percentage of hepatocyte nuclei positive for PARK7 from control to NAFL to NASH (p<0.001). Also, the grade of inflammation correlated positively with the percentage of hepatocyte nuclei positive for PARK7 (p=0.018). Conversely, there was a stepwise decrement in serum PARK7 levels from control to NAFL to NASH (p<0.001). Expression and nuclear accumulation of PARK7 may partly contribute to the pathogenesis of NASH. The level of PARK7 in serum may be a promising biomarker for NASH.
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| Free Research Field |
消化器内科学
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