2016 Fiscal Year Final Research Report
Regulation of liver cancer stem cells by cirrhotic liver microenvironment
| Project/Area Number |
26460994
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 肝細胞癌 / 癌幹細胞 / 肝硬変 / 微小環境 |
|---|
| Outline of Final Research Achievements |
Recent evidences suggest that hepatocellular carcinoma possesses cancer stem cells that play a pivotal role on local recurrence and distant organ metastasis after radical treatment. In this study, we found that fibroblasts secrets TGF-beta and induce the stemness in EpCAM+ hepatocellular carcinoma. This effect was mediated at least in part through the activation of H3K36 demethylase KDM2B to modify epigenetic memories and induce the population of EpCAM+ cancer stem cells. We further identified the six cytokines, potentially reflecting the activation of microenvironment of hepatocellular carcinoma, to predict the survival outcome of hepatocellular carcinoma patients who received sorafenib treatment.
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| Free Research Field |
消化器内科学
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