Analysis of pathogenesis of nonalcoholic fatty liver disease from recurrent disease after liver transplantation

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461000
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kyoto University
• Principal Investigator: Ueda Yoshihide 京都大学, 医学研究科, 特定講師 (90378662)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 非アルコール性脂肪性肝疾患 / 脂肪肝 / 脂肪肝炎 / 肝移植 / 肝細胞癌

Outline of Final Research Achievements

1. Recurrence of NAFLD after liver transplantation: Rate of occurrence of fatty liver and NASH after liver transplantation for cryptogenic cirrhosis were 69% and 41%, respectively. No significant risk factor for the occurrence was identified.
2. NAFLD after pancreatectomy: High degree of fatty liver occurred in 43 of 423 patients (10.2%) after pancreatectomy. Risk factors for the fatty liver were pancreatic cancer, and total pancreatectomy or pancreatoduodenectomy.
3. Genetic analysis of hepatocellular carcinoma in patients with NAFLD: TERT promoter mutations and 8p loss were identified as characteristic genetic change in hepatocellular carcinoma in patients with NAFLD.

Free Research Field

肝臓学