Study on regulation of immune target in hepatocytes using iPS cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461004
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kobe University
• Principal Investigator: Aoi Takashi 神戸大学, 科学技術イノベーション研究科, 教授 (00546997)
• Co-Investigator(Renkei-kenkyūsha): HOTTA Haku 神戸大学, 大学院保健学研究科, 教授 (40116249)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: iPS細胞 / 肝細胞 / 腫瘍免疫

Outline of Final Research Achievements

In the process of cancer initiation and development, escape from tumor immunosurveillance has been thought to be important. However its molecular mechanisms are still unclear. This study aimed to clarify regulatory mechanisms of the expression of immune target molecules induced by viral infection of human non-cancer hepatocytes by utilizing iPS cell technologies and establish a system for drug discovery targeting it.
In this study, we established a drug-inducible system for forced expression of each proteins encoded by hepatitis C virus in human iPS cell - derived hepatocytes. Using this system, we analyzed the regulatory mechanism of the expression of immune target molecules.

Free Research Field

幹細胞生物学