Research and development for liver regeneration therapy with higher-therapeutic effects using the higher-functioning cultured bone marrow mesenchymal stem cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461009
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Yamaguchi University
• Principal Investigator: TAKAMI Taro 山口大学, 医学(系)研究科(研究院), 講師 (60511251)
• Co-Investigator(Kenkyū-buntansha): 藤澤 浩一 山口大学, 医学(系)研究科(研究院), 助教 (00448284) ; 山本 直樹 山口大学, 大学教育機構, 准教授 (90448283)
• Research Collaborator: AIBE Yuki ; YONEDA Kenji
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 肝硬変 / 骨髄細胞 / 酸化ストレス / コラゲナーゼ活性

Outline of Final Research Achievements

For many liver cirrhosis (LC) patients, anti-viral therapy has enabled control and elimination of hepatitis virus, but substantial improvements in vital prognosis for decompensated LC have been prevented by liver fibrosis and hepatocellular carcinoma. To overcome these issues, we have been conducting clinical research to assess the safety of a less-invasive liver regeneration therapy that uses cultured autologous bone marrow mesenchymal stem cells (BMSCs) for decompensated LC. In this project, to develop a culture method for higher-functioning BMSCs that show both collagenase activity and the regulation of redox homeostasis, we finally identified specific factors to promote the proliferation of BMSCs through the analysis of cultured BMSCs that showed higher collagenase activity on a nanomaterial-coated dish that we developed.

Free Research Field

消化器内科学