Analysis of participation of miRNAs to lipid metabolic malfunction by hepatitis C virus

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461014
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Yokohama City University
• Principal Investigator: SAITO SATORU 横浜市立大学, 医学部, 准教授 (00275041)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ウイルス / 肝炎 / microRNA

Outline of Final Research Achievements

There are many reports so far for using host’s lipid metabolism for a hepatitis C virus (below HCV) and making the environment of the replication and infection profitable. It was considered whether the anti-viral effect could be expected by miRNA-33,　which participates in lipid metabolism,　restraining replication and infection of an HCV, but the effect wasn't indicated. On the other hand, the expression of miRNA-27 was accelerated in the liver of non-alcoholic steatohepatitis hepatitis (NASH) patients. This miRNA-27 can be a marker of improvement for fibrosis in HCV patients after treatment.

Free Research Field

医師薬学