Significance of HBV integration during hepatocarcinogenesis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461016
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Minami Masahito 京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (60326220)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: B型肝炎ウイルス / 肝発癌

Outline of Final Research Achievements

We have demonstrated that (1) integrated HBV genomes are often located near host genomes associated with cell growth, (2) integrated HBV genomes are frequently seen in the common fragile sites that are preferentially transcripted and translated during cell cycles, and (3) some HBV-integrated genes like hTERT are found in different cases as common integration sites. These findings suggest that HBV integration is not a random event and that it can give positive effects for affected host cells to survive and proliferate during chronic inflammation state.

Free Research Field

肝臓病学