2016 Fiscal Year Final Research Report
Elucidation of pancreatic beta cell differentiation and maturation mechanism by monoamines
Project/Area Number |
26461036
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
|
Research Institution | Tokyo Institute of Technology |
Principal Investigator |
Sakano Daisuke 東京工業大学, 生命理工学院, 助教 (40571039)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | インスリン / β細胞 / 分化 / 脱分化 / モノアミン / ドーパミン |
Outline of Final Research Achievements |
We screened compounds that promote cell proliferation of mouse pancreatic β cells using 3,000 low molecular weight compounds. As a result, Domperidon (DPD) which is an antagonist of dopamine D2 receptor (Drd2) was identified. And it was also revealed that DPD has a strong dedifferentiation suppressing effect and cell death suppressing effect in addition to an increase of self-replicating ability of β cell. Furthermore, the formation of a heterodimer between Drd 2 and the adenosine A 2a receptoris important to control cell differentiation, dedifferentiation, cell division and cell death (Sakano et al., Stem Cell R eports, 2015).
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Free Research Field |
発生学、細胞生物学、分子生物学
|