Identification of new nerve-delivered growth factor regarding pancreatic B cells

2017 Fiscal Year Final Research Report

• Project/Area Number: 26461042
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Okayama University of Science (2017); Tohoku Medical and Pharmaceutical University (2014-2016)
• Principal Investigator: Kiba Takayoshi 岡山理科大学, 理学部, 教授 (80285139)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 膵B細胞 / 神経因子 / 再生 / 増殖

Outline of Final Research Achievements

We found that vagal hyperactivity produced by ventromedial hypothalamic lesions stimulated cell proliferation of rat pancreatic islet B. Previously, we developed a new technique regarding high-quality RNA extraction from rat pancreas for cDNA microarray analysis. Results of cDNA microarray pick up several genes regarding new nerve-delivered growth factor of pancreatic B cells. Now, we conduct a mammalian vectors carrying the nerve-delivered genes, which are detected by microarray analysis. We believe that these new gene network analysis will lead to Pancreatic cancer and Diabetes Mellitus Treatment.

Free Research Field

消化器内科学