2016 Fiscal Year Final Research Report
Molecular basis for clinical cancer stem cell targeted photodynamic therapy
| Project/Area Number |
26461045
|
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
|
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| Research Institution | Tottori University (2015-2016)
Nagasaki University (2014) |
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Principal Investigator |
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 光線力学療法 |
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| Outline of Final Research Achievements |
We performed cellular experiments to explore molecular basis for squamous cell carcinoma stem cell based photodynamic therapy (PDT) using talaporphin sodium. The cells with igher levels of CD44 variant are to be targeted via cistine transporter-glutathione in which cells are to be resistant to oxidative stress. For this aim, we performed MTS and glutathione-generation assay in the setting of PDT under sulphasarazopirine (SASP) administration. The results showed SASP had nominal additional effects on PDT.
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| Free Research Field |
消化器内科
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